In the year 2053, the earth has been devastated by a military experiment gone awry. The ozone layer is gone, radioactive clouds drift across the plains, and unpredictable, intense bursts of ultra-violet sunlight (called "brights") incinerate anyone caught outside. In these conditions, a group of travelers are trying to get from the frontier town of Jericho to the paradise safe haven of Neon City: A doctor named Tom, an old man with a mysterious past, a prostitute, a spoiled rich girl, an untalented comedian, and a bounty hunter named Stark with his valuable prisoner Reno. They board an armored truck converted into a passenger transport driven by an ex-convict named Bulk. Along they way, the travelers deal with passing though radioactive Xander clouds, 150F degrees of "brights", unstable paved roads, and nomadic motorcycle riders who kill anyone venturing though their territory...

Peyton Westlake is a scientist who has discovered a way to produce synthetic skin. This could revolutionise skin grafting, except for one minor glitch; the synthetic skin degrades after 100 minutes of exposure to light. When gangsters attack Peyton, he is horrifically burnt, and assumed dead. In his quest for revenge, Peyton, aka the Darkman, is able to take on the appearance of anyone (using the synthetic skin,) but he's only got 100 minutes per disguise.